Personal reminiscence: combinatorial and discrete optimization problems in which I have been interested

Combinatorial Optimization Problems for Which Almostevery Algorithm

Consider a class of optimization problems for which the cardinality of the set of feasible solutions is m and the size of every feasible solution is N. We prove in a general probabilistic framework that the value of the optimal solution and the value of the worst solution are asymptotically almost surely (a.s.) the same provided log m = o(N) as N and m become large. This result implies that for...

I-36: Preimplantation Genetic Diagnosis - Where Have We Been and Where Are We Going

Preimplantation genetic diagnosis (PGD) is now considered routine in IVF laboratories with micromanipulation capability and access to genetic diagnostic services. The past two decades have witnessed a dramatic increase in the use of PGD, the number of cycles performed, and the indications for which PGD has been used. This increase has been mirrored by a slow, but steady, increase in the range o...

Recent Advances in Global Optimization for Combinatorial Discrete Problems

The optimization of discrete problems is largely encountered in engineering and information domains. Solving these problems with continuous-variables approach then convert the continuous variables to discrete ones does not guarantee the optimal global solution. Evolutionary Algorithms (EAs) have been applied successfully in combinatorial discrete optimization. Here, the mathematical basics of r...

The effect of virulence on cultivation of Theileria annulata strains in lymphoid cells which have been cultured in suspension

Mel – Personal Reminiscence†

On July 1, 1970, I started my fellowship in neonatology under the tutelage of Mary Ellen Avery. I entered her lab in the MacIntyre Building at McGill University in Montreal. There were no other fellows or techs working in her lab at the time. The lab was spacious but sparsely furnished. In one corner was a pneumatic surface balance, handbuilt, from the design of John Clements. A lab book lay on...